ja_mageia

DDI Toolbox

An online listing of ‘tools' and partnering forum for NF drug screening. If you have an NF screening model (cells, animal models) - or a drug you'd like to see tested for NF efficacy - submit them for listing in the DDI Toolbox.

Toolbox Submissions are accepted on a rolling basis.

IMPORTANT NOTE:  The drugs listed below are for research purpose only, they are NOT available for patients.

TOOLS AVAILABLE

In Vivo Models
Tool Description: Xenograft model - human dermal neurofibromas, plexiform neurofibromas, MPNST
CTF Identifier: 2007-07-009

Tool Description: Nf1ob2/2 transgenic mouse lacking Nf1 only in osteoblasts
CTF Identifier: 2007-07-011

Tool Description: Human MPNST In Vivo Explant Model
CTF Identifier: 2007-07-002

Tool Description: Conditional knockout NF1 mouse model of optic glioma
CTF Identifier: 2006-07-003

Tool Description: NF1 & related mouse models from The Jackson Laboratory
CTF Identifier: 2006-07-008

Tool Description: Xenograft model - MPNST, intraneural hypercelluar tumors
CTF Identifier: 2006-07-015

In Vitro Models
Tool Description: Human Dermal Neurofibromas & Derived Primary Cells
CTF Identifier: 2007-07-006

Tool Description: Human Pexiform Nerofibromas - primary cell lines
CTF Identifier: 2007-07-007

Tool Description: Human MPNSTs - primary cell lines
CTF Identifier: 2007-07-008

Tool Description: MPNST Cell Lines
CTF Identifier: 2007-07-001

Tool Description: MPNST Cell Lines
CTF Identifier: 2007-07-003

Tool Description: Primary Schwannoma NF2 Cell Model
CTF Identifier: 2006-07-002

Tool Description: Primary human NF1 and NF2 Cells from Coriell
CTF Identifier: 2006-07-007
Click here to view samples.

Drugs

Too Description:                PdLA
CTF Identifier: 2011-07-001

Tool Description: HDAC6 inhibitors
CTF Identifier: 2010-07-001
Company: Acetylon Pharmaceuticals

Tool Description: CI-1040
CTF Identifier: 2006-07-013
Company: Pfizer Inc.

Tool Description: Various new chemical entities
CTF Identifier: 2007-07-010
Company: AstraZeneca Pharmaceuticals

Tool Description: PTC124
CTF Identifier: 2007-07-005
Company: PTC Therapeutics Inc

Tool Description: Phospholipase Crotoxin - an anti-tumor agent
CTF Identifier: 2006-07-001
Company: Celtic Biotech Ltd

Tool Description: NPV-AUY922
CTF Identifier: 2008-07-001
Company: Novartis

Tool Description: PF-562,271
CTF Identifier: 2008-07-002
Company: Pfizer Inc.

Tool Description: Varinostat
CTF Identifier: 2008-07-003
Company: Merck Inc.

Tool Description: Small molecule PAK inhibitors
CTF Identifier: 2010-01-002
Company: Afraxis


NIH Clinical Collection: The NIH Clinical Collection (NCC), a plated array of approximately 450 clinically tested compounds, is now available for distribution through www.nihclinicalcollection.com.

Miscellaneous
Tool Description: Frozen Human Tumor Samples
CTF Identifier: 2007-07-004

Tool Description: Frozen Human Tumor Samples
CTF Identifier: 2007-07-014

TOOLS WANTED

In Vitro Models
Tool Description: Immortalized lymphocytic cell lines from patients with NF1 or NF2
CTF Identifier: 2007-13-002

Miscellaneous
Tool Description: Cloning of various NF domains
CTF Identifier: 2007-13-001

Questions?  Please contact Min Wong at This e-mail address is being protected from spambots. You need JavaScript enabled to view it or (212) 344-6633 ext. 242.