|
Jul 21
2010
|
The News About Avastin and Breast Cancer: Some ThoughtsPosted by: Kim Hunter-Schaedle on Jul 21, 2010 |
|
In the news this week, a Food and Drug Administration advisory panel is recommending that the drug Avastin (bevacizumab), the best selling product of Roche (developed by its Genentech unit) has its 2008 approval for advanced breast cancer treatment revoked. Taking back a drug approval is something the FDA rarely does. Avastin is of course a drug of high interest as a candidate NF2 therapy: following a Harvard-based clinical trial of the drug published in the New England Journal of Medicine last summer other studies and assessment of Avastin in NF2 have ensued, an area that CTF is currently tracking through our Avastin Survey.
The rationale for revoking Avastin’s breast cancer approval is that while the first clinical trials looked promising, to the point that some hailed Avastin as a 'miracle' drug, follow up studies showed that Avastin doesn’t extend women’s lives by a statistically significant amount, a measure that is considered a ‘gold standard’ for cancer drugs. The full picture is yet to emerge – for example, are some patients responding and others are not (perhaps due to genetic differences), giving an overall mixed result? Will Avastin have more effect used in conjunction with another drug (currently being investigated?) Some questions are tougher to answer: if someone’s life is extended by a handful of days or weeks because of Avastin, can we rationalize that out of the picture because it is ‘not statistically significant?’
Regardless, the FDA advisory panel recommendation has the broadest interests of the public in mind. The arena of looking for effective drug treatments is not a venue for miracles, but for careful, thoughtful work. Avastin will continue to be used and assessed in lung cancer and colon cancer and despite the revocation if it comes, in breast cancer too, in the context of clinical trials for those patients with the resources to access the drug. For NF2, we are seeing a glimmer of promise for Avastin as a treatment. While we can’t know what lies ahead, we will continue to track the progress of Avastin trials and support further investigation into its success in treating NF2 and other potential treatments.

written by ghd hair straightene, August 28, 2010
written by sean.waches, August 29, 2010
Diamond has business worth in a lot of areas. We can make cash by diamond in jewelry industry, in industrial location and engineering location, considered as discussed on this passage. Hope that a single day latest approach is designed to ensure that we could make full use of diamond and its business values.
written by sean.waches d, August 29, 2010
Diamond has business worth in a lot of areas. We can make cash by diamond in jewelry industry, in industrial location and engineering location, considered as discussed on this passage. Hope that a single day latest approach is designed to ensure that we could make full use of diamond and its business values.
written by air jordan , September 18, 2010
written by bagonahnd, September 18, 2010
the bag was larger than I expected. After about a month of use, I love this bag!It's size is perfect for big city commuting to the office. Everything I need for the day, including my office heels, fits. My things are organized, all within easy reach in the different compartments, and the whole bag fits under my arm so subway rides aren't cumbersome. I very much recommend this bag to anyone who needs a classy bag that still carries all the necessities!We supply famous brands, designers and classic look and the latest trends for your handbag, we offer the best quality, reasonable prices, fast shipping, handling shipping is available, the best and timely service.Welcome to our site selection at any time, wish you a pleasant online shopping.:http://www.bagonhand.com
NBA jersey seems simple and plain style which doesn't lose its blaze and flashes with different values in different people's eyes! The Designer of pandora bracelets Changed In players'eyes,it symbolizes their locations on court and embodies the position of the team; in the eyes of club bosses, its sale is the source of profits.nba Jerseys In the fan'eyes, it is symbol of their idols. It is a dream come true to have the jerseys of their idols; And in the eyes of the science and technology workers,its texture needs to be revamped, and the styles need to be diversified.Style Provided at Low Price! Get links of london sale for Nephews!In the street, we see vitality full of youthful spirit and prosperity from a handsome man in jersey. More info.:
http://www.nfljerseyonline.com/
written by fake rolex, September 20, 2010
rolex replica watch,
replica rolex watch,
fake tag watches
fake watches .You can find almost all the replica Rolex series there. They have Latest style and classic style. Though their price
are low,don’t worry about it’s quality.Every detail of replica rolex shows its original marvelous designs and the best imitation
technology. I have bought from them for so many times, and very satisfied with the their goods and service. Come on, choose one you love it.
written by gucci bags, October 20, 2010
written by bagonhand, October 20, 2010
NBA jersey seems simple and plain style which doesn't lose its blaze and flashes with different values in different people's eyes! The Designer of pandora bracelets Changed In players'eyes,it symbolizes their locations on court and embodies the position of the team; in the eyes of club bosses, its sale is the source of profits.nba Jerseys In the fan'eyes, it is symbol of their idols. It is a dream come true to have the jerseys of their idols; And in the eyes of the science and technology workers,its texture needs to be revamped, and the styles need to be diversified.Style Provided at Low Price! Get links of london
sale for Nephews!In the street, we see vitality full of youthful spirit and prosperity from a handsome man in jersey. More info.:
http://www.nfljerseyonline.com/
written by moncler, November 18, 2010
http://www.monclerleather.com/
written by coln, December 04, 2010
mbt M.Walk shoesmbt kimonda shoesmbt salama shoesskechers shape upsMoncler jacketMoncler Vest Moncler sweaterWomen Moncler down coatMan Moncler down coatUGG bootswomen UGG bootsDiscount UGG bootsLadies UGG bootsLadies UGG boot
Asics ShoesDiscount Asics ShoesAsics Women ShoesAsics Man ShoesAsics Shoes saleBuy Discount Asics ShoesAsics Gel Kinsei 2 ShoesAsics Gel Stratus 2.1 ShoesAsics Japan Ar ShoesAsics Whizzer Lo ShoesAsics Women ShoesOnitsuka Tiger California 78 ShoesOnitsuka Tiger Mexico 66 ShoesOnitsuka Tiger Mexico 66 Deluxe ShoesOnitsuka Tiger Mexico 66 Lauta ShoesOnitsuka Tiger Mexico Mid Runner ShoesOnitsuka Tiger Rotation 77 ShoesOnitsuka Tiger Tokidoki Mex Lo Shoes
Timberland ShoesDiscount Timberland ShoesTimberland Shoes SaleBuy Timberland ShoesTimberland Shoes ClearanceTimberland WomenShoesTimberland Men ShoesTimberland Children Shoes
written by Christian louboutin, March 08, 2011
written by office 2010, September 20, 2011
written by Retro Jordan, December 01, 2011
Action is a kind of medicine for fear, and hesitation only will continue to nourish the fear.
written by cheap air jordan, December 01, 2011
555ce26
Things do something great, detail achievement perfect.











“Oh, nothing, Mum” replied Tom. “I’m eating my cake. coach handbags He is crying
because I won’t give him any.”
“But has he finished his own cake?”
“Yes.” said Tom. “And he also cried when I was helping him finish that coach bags on
sale .”