MRI Bright Spot

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MRI Bright Spot

Postby sonya489 » Mon Sep 09, 2002 3:36 pm

I know that I have read somewhere about bright spots on the MRI's and what they mean but now I can't remember what it was.Does anyone know what it means.
Thank,
C-YA
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MRI Bright Spot

Postby Vandaar » Mon Sep 09, 2002 5:40 pm

UBO's are just what they sound like bright spots on the brain. Basicly the tissue here has a little more water than the surrounding tissue. Water shows up on MRIs.

There hasnpt been any correlation between UBOs and bright spots. They tend to just go away in time.

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MRI Bright Spot

Postby sonya489 » Tue Sep 10, 2002 2:23 am

I have been reading so much latly that everything is kind of running together.Isn't there some relationship in some children with the UBO's and learnning disoders? Isn't this also used as a criteria for NF1 now or am I mistaken about that? There is no relationship at all to UBO's and tumors correct?
We have a Neurologist appt. next Monday & Opthamologist next Tuesday.

Thanks,
C-YA
Sonya
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MRI Bright Spot

Postby Noor's mom » Tue Sep 10, 2002 2:52 am

We have our neurologist appointment on the 18th, to interpret the MRI's for 3 of us. Maybe we
can compare notes after that.
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MRI Bright Spot

Postby sonya489 » Tue Sep 10, 2002 6:11 am

I would love to compare notes with you so keep me posted and I will post after my son's appts.

Thanks,
C-YA
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MRI Bright Spot

Postby Guest » Tue Sep 10, 2002 7:38 am

Trevor did not show UBOs (bright spots) on his first MRI, but did on his second. I do remember reading there was a study that correlated UBOs and Learning Disabilities, but then there were other studies that did not support this theory. Right now the geneticist tells us they really don't understand the significance of them and not to worry, most children have them and that they go away over time. It will be interesting to see what more years of research bring. We are still in such an infantile stage of understanding this disorder... much more will come over time.

Love to hear your specialists take on things <img border="0" title="" alt="[Smile]" src="smile.gif" />
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MRI Bright Spot

Postby sonya489 » Tue Sep 10, 2002 10:13 am

I understand that the bright spots are consistant but aren't used as far as a criteria it's seems like if all the kids have these bright spots they ought to be able to put in into a diagnosis criteria.Some of these things are so confusing.Our son is still having the headaches and vison problems & complaints of his stomach bothering him thank goodness the vomiting stopped.He is struggling so bad at school right now even with modified work.
Thanks,
C-YA
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MRI Bright Spot

Postby seesnow » Tue Sep 10, 2002 8:17 pm

UBOs are consistent with NF, but are not on the criteria list for it....the reason being that people with MS also get UBOs as well as a very small amount of the general population. Like Trevor's Mom said, some people try to tie them to learning disabilities and others refute that - hence the "Unidentified". Thankfully, they do fade towards adulthood. Timmy already had one disappear and he is only 3! <img border="0" title="" alt="[Smile]" src="smile.gif" />
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MRI Bright Spot

Postby sonya489 » Wed Oct 23, 2002 11:11 am

HI ALL,
I have been waiting for the neurologist to see the MRI reports on our son well the pediatrician didn't seem to get him a copy of the report or the MRI SLIDES so we have been waiting awhile. Today they called he has the report still no slides I will have to go take care of it myself I guess I should of already done it...
He says: The bright spot on Jeremy's MRI report he feels like is related to the neurofibromatoses I know this isn't a criteria but what does it mean?
Jeremy has no lish nodules,or under the arm freckling he just has the cafe'au lait spots.
Jeremy's vision was off slighlty so we did get glass to help with that. The migranes have gotten better for now.

The school did some testing on learning dissabilities and nothing showed a definite problem in specific areas but there is some problems just not enought to fall under any 504 right now without the medical end of it.
We also did the Conners index the teacher and I.
Ok on this rating thing the scales are as follows:
40-90 40 being low 90 being high as far as ADHD goes.
The teacher rated him a 75 and we rated him a 80 it says above 65 is considered a high risk of being AHDH does anyone understand this better than me?
I have requested the neurologist reqest neurophyscological (sp) testing under a medical neccesity which he has agreed to.The insurance will pay for it this way. He says the school testing is not that detailed as having it done on your own? What do yall think?

Thnaks,
Sonya
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MRI Bright Spot

Postby clueless_john_galt » Wed Oct 23, 2002 12:03 pm

MRI bright spots ( and please someone w/more knowledge correct me ) are areas of HIGH-SIGNAL-INTENSITIES - the "physical" indications are that the "only" physical irregularity of the brain tissue at the location of the UBO is "a little more intra-cellular (between the cells) fluid/water. I believe this has to do w/growth rates of the brain tissue as affected by the gene-deletion that is NF. The areas of high signal intensity "COULD" represent the failure of the NF patients' brain to properly process or normally deal with "brain signals" where at the point where the UBO is found...the neurons are having a hard time allowing the "thought" or nerve signal to pass or "process" and because of the failure of the signal to smoothly "get through" the signal kind of "corrupts" and adjoining neurons attempt to properly process the signal. Meaning that as a signal is transmitted - it reaches a bottleneck, and as the signal continues it creates an area of neurons that are firing-off signals or "their own interpretations and attempts" of the signal that didn't quite get through or processed correctly.

An analogy ( like, but not exactly the same ) can be found in comparisson to epilepsy - where the UBO represents a "fire-storm" of signals all at the same time - though over larger portions of the brain.

I think that some researchers think that these areas where you find UBO's in NF patients are areas that in the end - are areas/parts of the brain where the processes of normal functioning are being disrupted and ultimately responsible for Non-Verbal Learning Disorders.

Beyond that what I can report that I have learned is that UBO's seem to "disappear" and quietly go away....as the person reaches adulthood. That the "localized" firestorms of neuronal activity represented by UBO's eventually train the childs' brain to "get the process complete" to "process the signal" that's having a hard time getting thru.

Imagine it this way. Lets say a child is walking to school. Pointed in the right direction, mommy sends him off walking towards the school w/a pat on the back. The most direct route though is blocked ( unbenounced to his parents ) by road construction. So faced with the obstacle, the child ( the signal ) trys all the alternate routes available at the location the roadblock is found. The child trys the alleys, the next street over ( in both directions ) and the alleys in between....all trying to reach the school. Eventually the signal gets through - the kid reaches school....but did he make it there without impediment? No. something along the path interferred with his ability to "go directly to school"....that being the resultant extra-fluid/water between the cells ...resultant from the not quite right "rates of growth" of brain tissue found in NF folks....

Think about your ability to express yourself. You know when you have exactly the idea that you want to convey....but for some reason it's not quite comming out as clearly as you invision the idea....kind of like a "fog" around the idea....like a haze of electrical signals pushing through to get whatever understanding the brain normally makes of the stimulus. There is an imparement there but the only identifiability is through what scientists know of brain-function in corellation with the location of the UBO.

Ask your Dr. to identify the locations of the UBO's and to corelate the locations w/typical brain function at those locations. They may correlate with communication-processing....resulting in the Attention-Deficit-Disorder....is the kid processing what he's seeing on the blackboard properly? does the same deficit occur when material is delivered instead in another format ( spoken word vs. written ideas on the black board ).

Im no doctor although I have a strong med background & a good science edu. all these ideas are what I have conveyed to you based upon my readings of the research I can find on the web or else where and my understandings of them.
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