Clinical Research Awards

Introduction

The Pre-Application to the 2016 Clinical Research Awards is now available.

Please be sure to review the applicant information and guidelines ( link ) before applying.

Pre applications are due Monday June 20th, 2016 at 5pm EST.

Access the Pre-Application here.

We look forward to receiving your applications!

To accelerate NF research, CTF launched the Clinical Research Award (CRA) program in 2007 to support early stage pilot clinical trials of candidate therapeutics or interventions for treatment of manifestations of NF1, NF2 and schwannomatosis. In addition, these awards support innovative clinical trial enabling studies.

It is hoped that applications for Clinical Research Awards will be broad-thinking, novel ideas. Examples of projects encouraged may include but are not limited to the following:

  • Preclinical/clinical collaborative studies. Note that all studies must include a clinical element – preclinical-only studies are not eligible
  • Pilot clinical trials (CTF leverages our relationship with industry or larger funding organizations to provide drug at no cost to successful applicants.)
  • Clinical enabling studies such as biomarker and patient stratification that may better inform and help accelerate a clinical trial.

It is anticipated that CTF will fund up to three Clinical Research Awards of up to $150,000 (including overheads and indirect costs).

For application information, please refer to the research awards schedule here.

NF Clinical Research Awardees

2014 Funded Clinical Trial Awards

A Study of INFUSE Bone Graft (recombinant human Bone Morphogenetic Protein-2/absorbable collagen sponge) in the Treatment of Tibial Pseudoarthrosis in Neurofibromatosis 1 (NF1). Dr. Bruce Korf, University of Alabama at Birmingham

Phase 1 trial of combined MEK and mTOR inhibition in MPNSTs. Dr. Aerang Kim, Children’s Research Institute

Resiliency training for adolescents with NF1 and NF2.Dr. Ana-Maria Vranceanu, Massachusetts General Hospital


2013 Funded Clinical Trial Awards

Good manufacturing practice of clinical grade advanced-therapy medicinal product in regenerative therapy for congenital pseudarthrosis of the tibia in 5 individuals with neurofibromatosis type 1, Dr. Eric Legius

The Impact of Ras/MAPK signaling pathway-targeted therapies on neurocognitive functioning in youth with NF1, Dr. Karin Walsh, Children's Research Institute

Resiliency training for patients with Neurofibromatosis via videoconferencing with Skype, Dr. Ana-Marie Vranceanu, Massachusetts General Hospital


2012 Funded Clinical Trial Awards 

A Phase II Randomised Placebo-Controlled Double-Blind Cross-Over Trial of Methylphenidate in Children with Neurofibromatosis Type1, Dr. Kathryn North, The Children’s Hospital at Westmead

Effect of creating visual illness narratives on quality of life in children with Neurofibromatosis type 1: a pilot intervention study, Dr. Nicole Ullrich, Boston Children's Hospital

Effect of anti-VEGF and radiation on NF2 vestibular Schwannoma Schwannoma, Dr. Lei Xu, Massachusetts General Hospital                              


 2011 Funded Clinical Trial Awards 

Phase II Trial of Rapamycin - NF2 Tumors
Dr. Matthias Karajannis, New York University Langone Medical Center

New metrics for optic pathway glioma trials
Dr. Robert Avery, Children’s National Medical Center

Blood predictors of NF1 severity
Dr. Cynthia Hingtgen, Indiana University

Computerized ‘maze’ for NF1 learning disabilities trials
Dr. Nicole Ullrich, Children’s Hospital Boston

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